Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells

Bioorgan. Med. Chem. 2013;21(22):7107-7117
Draoui D, Schicke O, Fernandes A, Drozak X, Nahra F, Dumont A, Douxfils J, Hermans E, Dogné JM, Corbau R, Marchand A, Chaltin P, Sonveaux P, Feron O, Riant O
Date of publication: 
Friday, 15 November 2013

We report the identification and characterization of a new family of compounds that act as anticancer drugs through inhibition of MCT-dependent lactate transport.