Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration

Oncogene 2013; doi: 10.1038/onc.2013.454
De Saedeleer CJ, Porporato PE, Copetti T, Pérez-Escuredo J, Payen VL, Brisson L, Feron O, Sonveaux P
Date of publication: 
Wednesday, 11 December 2013

Our study identifies a functional link between impaired mitochondrial activity and tumor cell migration wherein the mitochondrion acts as a glucose sensor and signals via ROS MCT1-dependent tumor cell escape to a more favorable metabolic environment.