Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration
Oncogene 2013; doi: 10.1038/onc.2013.454
Date of publication:
Wednesday, 11 December 2013
Our study identifies a functional link between impaired mitochondrial activity and tumor cell migration wherein the mitochondrion acts as a glucose sensor and signals via ROS MCT1-dependent tumor cell escape to a more favorable metabolic environment. http://www.ncbi.nlm.nih.gov/pubmed/24166504
