Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer

Plos ONE 2013:8(9):e75154
Kennedy KM, Scarbrough PM, Ribeiro A, Richardson R, Yuan H, Sonveaux P, Landon CD, Chi JT, Pizzo S, Schroeder T, Dewhirst MW
Date of publication: 
Thursday, 12 September 2013

Kinetic uptake rates of lactate in vivo surpassed that of glucose in R3230Ac mammary carcinomas. The uptake appeared specific to aerobic tumor regions, which is consistent with the ‘‘metabolic symbiont’’ hypothesis.