Professor in Orthopaedic Surgery, Department of Biomedical and Neuromotor Sciences, University of Bologna, Italy. He is also a staff surgeon, Orthopaedic Oncology, Clinica Ortopedica e Traumatologica I, and Head of the Orthopaedic Pathophysiology and Regenerative Medicine Lab, Istituto Ortopedico Rizzoli, Italy. Member of the Faculty of the PhD Program in Biomedical Sciences, University of Bologna. Bone cancer has been always one of his main research interests, and his research activity has recently focused on the role of proton dynamics in tumor survival, invasiveness, and chemoresistance in bone tumors, with a particular interest in cancer stem cells. Works are supported by the Italian Association for Cancer Research and from the Ministry of Research and Education.