Early Stage Researcher (ESR/PhD) in the Marie Skłodowska-Curie ITN European Training Network “TRANSMIT – TRANSlating the role of Mitochondria in Tumorigenesis” (H2020-MSCA-ITN-2016) - ESR 3 (Justus Liebig University of Giessen, Germany)
TRANSMIT - TRANSlating the role of Mitochondria in Tumorigenesis
The consolidation of the knowledge that cancer is not only a genetic, but also a metabolic disease, has led scientists to investigate the intricate metabolic plasticity that transformed cells must undergo to survive the adverse tumor microenvironment conditions, and the contribution of oncogenes and tumor suppressors in shaping metabolism. In this scenario, genetic, biochemical and clinical evidences place mitochondria as key actors in cancer metabolic restructuring, not only because these organelles have a crucial role in the energy and biosynthetic intermediates production but also because occurrence of mutations in metabolic enzymes encoded by both nuclear and mitochondrial DNA has been associated to different types of cancer. TRANSMIT aims to dissect the metabolic remodeling in human cancers, placing the focus on the role of mitochondria and bridging basic research to the improvement/development of therapeutic strategies. Further, TRANSMIT fosters the communication of this emerging field to the patients and their families. To these aims, TRANSMIT will create a network of seven different countries, among which world-leading basic science and clinical centers of excellence, several industrial partners with up-todate omics technologies, as well as non-profit foundations and associations who care for cancer patients. By creating the critical mass of scientific excellence, TRANSMIT will allow to transfer the current knowledge into the wide field of cancer research, translating scientific and technical advances into the education and training of eleven Early Stage Researchers. TRANSMIT will implement training-through-research dedicated to unravel the metabolic features of cancer, as well as to provide a full portfolio of complementary skills through the creation of a network of basic, translational and industrial laboratories, devoted to a multidisciplinary/multisectorial education of young scientists.
1) Job Summary: ESR (Early Stage Researcher) position for 36 month at the Institute of Veterinary Physiology and Biochemistry, Justus-Liebig-University of Giessen, Germany
2) Job description: Application refers to an Early Stage Researcher (ESR) position available in the H2020 Marie Skłodovska Curie Innovative Training Networks to be trained at the Department of Veterinary Physiology and Biochemistry, University of Giessen, Germany
Cancer cell proliferation strongly depends on the availability of energy and metabolic precursors for the synthesis of cell building blocks which implies a close coordination between the associated key pathways glycolysis and glutaminolysis. The ESR will investigate the effect of different nutrient deficiency protocols as well as inhibitors of selected cytosolic and mitochondrial enzymes on the composition of the glycolytic enzyme complex as well as the coordination of the glycolytic and glutaminolytic conversion rates in tumor cell lines with different metabolic characteristics. In selected cell models with most effective treatment protocols the metabolic fate of glucose and glutamine will be determined using mass spectrometry.
3) Subject area of PhD program in which the ESR will be enrolled and PhD program duration: PhD programme of the Faculties of Veterinary Medicine and Medicine; Section Metabolism; Duration 3 years
4) Host University that will provide the PhD degree: Justus Liebig University of Giessen, Germany
5) PhD program starting date: October 1st, 2017
Required Educational Level
Degree: Master Degree in Biology, Biochemistry, Biotechnology, Nutritional Sciences, Chemistry or Completed University Degree in Veterinary Medicine or Medicine
Degree Field: Biochemistry, Cellular and Molecular Biology, Molecular Genetics
Skills: highly motivated, team player, self-organized, goal orientated working style. Experience in a research lab, proficiency in basic techniques in Biochemistry and / or Cell Biology, i.e. cell culture, ectrophotometry, western blotting, PCR are of benefit.
Languages: Fluent written and spoken English is mandatory. Basic knowledge in German is an advantage.
Applications, in English, should include CV, detailed academic transcripts, a copy of the master thesis, a motivation letter and at least one reference letter from a former supervisor or lecturer, which are all to be submitted until May 1st, 2017 by Email to Prof. Dr. Sybille Mazurek (Email: Sybille.Mazurek@vetmed.uni-giessen.de).
Elegibility: The applicants must be in possession of a degree in Biochemistry, Biology, Biotechnology, Nutritional Sciences, Chemistry, Veterinary Medicine or Human Medicine at the date of recruitment - an ‘early stage researcher’ (i.e. in the first four years of his/her research career and not have a doctoral degree).
The applicant may be a national of a Member State, of an Associated Country or of any other Third Country.
The applicants not have resided in the country where the research training activities take place for more than 12 months in the 3 years immediately prior to the recruitment date and not have carried out their main activity (work, studies, etc.) in that country.
· Enrollment in a PhD school in a specific area
· 3-year employment contract (total gross amount for three years: 110.616,48 Euro living cost plus 21.600,00 Euro mobility allowance plus familiar allowance depending upon the familiar status of the applicant at the time point of recruitment.
· A highly multidisciplinary, cross-cultural and competitive training program in the field of metabolism in cancer (or molecular oncology)
· Secondments and a specific training program
· Vacation days/year: 30 days
First selection step: Curriculum evaluation. Numerical scores will be awarded for grading criteria such as study marks, duration of study, scientific publications in peer reviewed journals, reference letters. Only the admitted candidates will be contacted by e-mail for the second selection step.
Second selection step: Skype, phone or face-to-face interview in which candidates will give a short presentation of their master thesis and of a scientific paper that they will receive two to three weeks before the interview.
The University seeks to increase the number of its female faculty and staff members. Therefore qualified women are strongly encouraged to apply.
Evaluation period: 4 weeks