2 postdoctoral positions in Prague, Czech Republic

Thursday, 12 January 2017
Tuesday, 28 February 2017

Department of bioenergetics, Institute of Physiology CAS is looking for 2 highly motivated postdoctoral fellows with Ph.D. or equivalent degree to work on GA CR (Czech Science Foundation) funded projects. The contracts are fixed till December 31, 2018 but with potential for prolongation from other sources. You will get the opportunity to become a member of our young and dynamic team based in state of the art facilities within the biomedical campus of the Czech Academy of Sciences located at the outskirts of Prague. For details about the department, you can check our webpage:  http://fgu.cas.cz/en/departments/bioenergetics. Applications will be accepted until the position is filled.

Position 1: Characterisation of the role of DAPIT protein in the biogenesis of mammalian mitochondrial ATP synthase (PI and the head of department: Tomas Mracek)


Recently, we have developed rat knockout model for DAPIT subunit with not yet known function in this enzyme complex. This project will focus on characterisation of enzyme biogenesis and biochemical function in control versus knockout animals. Other branch will focus on whole body phenotyping of metabolic functions in knockout animals to establish organ specificity and develop our understanding how compromised mitochondrial energy provision can influence/dictate metabolic phenotypes.

Position 2: Mitochondrial glycerol-3-phosphate dehydrogenase as a target for anti-tumour therapies (PI: Alena Pecinova)

Mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase (mGPDH) is inducible and highly tissue/cell specific enzyme typically active in glycolytic cells.  Main aim of this project is to verify mGPDH as a potential druggable target in tumour cells and confidently identify those cancer cell lines which are negatively affected by traditional and novel mGPDH inhibitors. Project will include work on tumour cell lines, biochemical characterisation of inhibitors’ mode of action and data mining for tumour types, which are dependent on mGPDH.

Applicants should fulfil following criteria:

  • Have completed the PhD before start of the contract.
  • Have a strong track record in one or more of the following areas: biochemistry, cell biology, molecular biology, or animal physiology. Experience with –omics data analysis is also welcome.
  •  Be fluent in English.

The applications should be sent to tomas.mracek@fgu.cas.cz and contain:

  • Curriculum Vitae.
  • List of publications / summary of previous research experience
  • Recommendation letters or (preferably) e-mail contacts to two referees – at most one from the applicant’s current affiliation.
Phd in biochemistry, cell biology or similar
500,000 CZK / year
Institute of Physiology of the Czech Academy of Sciences
Job type: 
Prague, Czech Republic